Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


May 20 2021 - 2:00pm to 3:15pm
Prof. Daniel Knopf
Stony Brook University


BMO Capital Markets Innovators' Challenge

Solutions to health care’s greatest challenges won’t come from one idea or person. They’ll come from a community of innovators and investors, using their time, talents and financial support to create change system-wide.

On May 6, the BMO...

Particles showing 3 liquid phases. Credit: Yuanzhou Huang

Scientists discover three liquid phases in aerosol particles

Findings could help explain how air pollutants interact with the atmosphere

Researchers at the University of British Columbia, University of California Irvine, and McGill University have discovered three liquid phases in...