Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Jul 8 2021 - 9:00am to 12:00pm
Jennifer Yuan
UBC Chemistry (Wolf Group)
Jul 15 2021 - 12:30pm to 3:30pm
Christopher Walters
UBC Chemistry (MacLachlan Group)


Chemistry Welcomes New Faculty Member Dr. Ilsa Cooke

The Department of Chemistry is pleased to announce the appointment of Dr. Ilsa Cooke as an Assistant Professor in the area of experimental physical chemistry with a focus on astrochemistry. She will join the department January 1st , 2022.


8 Chemistry Professors Receive a Total of $1.985 Million in NSERC Funding

Congratulations to the 8 Chemistry Professors that received funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grants to support long-term research goals! The 8 Chemistry Professors are: Jason Hein, Eva...