Interrogating the thionium hydrogen bond as a noncovalent stereocontrolling interaction in chiral phosphate catalysis

CH⋯O bonds are a privileged noncovalent interaction determining the energies and geometries of a large number of structures. In catalytic settings, these are invoked as a decisive feature controlling many asymmetric transformations involving aldehydes. However, little is known about their stereochemical role when the interaction involves other substrate types. We report the results of computations that show for the first time thionium hydrogen bonds to be an important noncovalent interaction in asymmetric catalysis. As a validating case study, we explored an asymmetric Pummerer...


Mar 28 2023 - 12:45pm to 2:00pm
Dr. Xuanhe Zhao
Department of Mechanical Engineering, Massachusetts Institute of Technology
Mar 29 2023 - 5:00pm to 6:00pm
Tian Zhang
University of British Columbia
Mar 31 2023 - 1:00pm to 2:00pm
Julian G West
Rice University


Congratulations Zac Hudson!

Congratulations to Associate Professor Zac Hudson for being a recipient of the UBC Killam Accelerator Research Fellowship & the Charles A. McDowell award!

Dr. Hudson’s research on optoelectronic materials spans the fields of organic,...

Chemistry Alum Gets a Positive Reaction to Debut Novel

On International Women's Day we'd like you to meet UBC Chemistry alum Dr. Emily Seo, author of "The Science of Boys", a fun rallying call for girls and women in STEM.

Read the full story...