Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Apr 19 2021 - 10:00am to 11:00am
Dr. Kelvin Anggara
Department of Nanoscale Science, Max Planck Institute for Solid State Research
Apr 19 2021 - 12:30pm to 3:30pm
Weiying He
UBC Chemistry (Kennepohl & Mehrkhodavandi Groups)
Apr 20 2021 - 1:00pm to 3:00pm
Yingyue Zhang
UBC Chemistry (Chou Group)


Particles showing 3 liquid phases. Credit: Yuanzhou Huang

Scientists discover three liquid phases in aerosol particles

Findings could help explain how air pollutants interact with the atmosphere

Researchers at the University of British Columbia, University of California Irvine, and McGill University have discovered three liquid phases in...

Takamasa Momose poses with the laser system at UBC. The main components of the system were designed and built by Momose and students in his lab. Credit: Takamasa Momose

World’s First Anti-Molecule Could Become a Reality Thanks to Laser-Cooled Antimatter

Researchers cool antimatter for the first time.

Researchers at the CERN-based ALPHA collaboration have cooled antimatter to near absolute zero for the first time,...