Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Aug 5 2021 - 9:30am to 12:30pm
Maria Cleveland
UBC Chemistry (Brumer Group)
Aug 8 2021 - 1:00pm to Aug 10 2021 - 4:00pm
Jeffrey Suen
UBC Chemistry (Gates Group)
Aug 9 2021 - 9:00am to 12:00pm
Paul Foth
UBC Chemistry (Sammis Group)


Image of Prof. Zac Hudson holding sustainable coffee pods

Prof. Zac Hudson helps develop sustainable coffee pods

Dr. Zac Hudson, an assistant professor and Canada Research Chair in Sustainable Chemistry has been working with NEXE Innovations to develop sustainable coffee pods. These coffee pods are made up of two materials: an outer fibre jacket and a...

8 Chemistry Professors Receive a Total of $1.985 Million in NSERC Funding

Congratulations to the 8 Chemistry Professors that received funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grants to support long-term research goals! The 8 Chemistry Professors are: Jason Hein, Eva...