Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Dec 7 2021 - 12:45pm to 2:00pm
Sarah E. O’Connor
Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology
Dec 8 2021 - 4:00pm to 5:00pm
Dr. Menghua Wang
Department of Chemistry, University of British Columbia


2021 Alumni Award Winners

At our November Alumni Reunion, we announced the winners to our two alumni awards. Congratulations to Prof. Chris Gill, who is awarded the Alumni Award of Distinction, and Dr. Shuai Sherry Zhao, who has been awarded the Young Alumnus Award!


November 2021 Chemistry Alumni Reunion

Our November 2021 Alumni Reunion was a great success! Thank you to all our attendees who joined us virtually and to Tao Huan and Emily Chung for their inspiring talks.

This years event also featured the announcement of our Graduate Student...