Enhancing Metabolome Coverage in Data-Dependent LC–MS/MS Analysis through an Integrated Feature Extraction Strategy

In untargeted metabolomics, conventional data preprocessing software (e.g., XCMS, MZmine 2, MS-DIAL) are used extensively due to their high efficiency in metabolic feature extraction. However, these programs present limitations in recognizing low-abundance metabolic features, thus hindering complete metabolome coverage from the analysis. In this work, we explored the possibility of enhancing the metabolome coverage of data-dependent liquid chromatography–tandem mass spectrometry (LC–MS/MS) results by rescuing metabolic features that are missed by conventional software. To achieve this goal...


Dec 12 2019 - 3:00pm to 4:00pm
Dr. Jolene Reid
University of Utah, Department of Chemistry, Marie Curie Fellow
Jan 7 2020 - 12:45pm to 2:00pm
Dr. Junko Yano | McDowell Lecture
Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory
Jan 14 2020 - 12:45pm to 2:00pm
Dr. Molly S. Shoichet | Xerox Lecture
Chemical Engineering & Applied Chemistry, University of Toronto


Rubber Materials that Change Colour when Stretched

Congratulations to Charlotte Boott and Andy Tran (from the MacLachlan lab) whose recent paper was published in Angewandte Chemie and identified by the reviewers as a very important paper (VIP). In this work, Charlotte and Andy developed an...

The Department Mourns the Passing of Dr. William R. Cullen

Dr. William R. Cullen, FRSC, Professor Emeritus (Inorganic and Environmental Chemistry) passed away on December 1st, 2019. He was 86 years old.


Bill, a New Zealand cricketer with a knack for chemistry, from Dunedin on the South...