Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Sep 21 2021 - 12:45pm to 2:00pm
Dr. David Wishart I Laird Lecture
Departments of Computing Science and Biological Sciences, University of Alberta
Sep 23 2021 - 9:00am to 10:30am
Dr. Claudia Marcolli
Institute for Atmosphere & Climate, Swiss Federal Institute of Technology (ETH Zürich)
Sep 24 2021 - 9:00am to 12:00pm
Hyungki Kim
UBC Chemistry (Algar Group)


Tao Huan Selected as a 2021 ASMS Emerging Investigator

Assistant Professor Tao Huan has been selected as one of 11 individuals for the American Society for Mass Spectrometry (ASMS) 2021 Emerging Investigators.

“The goal of the Emerging Investigators is to showcase some of the exciting...

Curtis Berlinguette Elected as Fellow of the Royal Society of Canada

The fellowship of the RSC comprises over 2,000 Canadian scholars, artists, and scientists, peer-elected as the best in their field. These are distinguished faculty from all branches of learning who have made remarkable contributions in the arts,...