Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...


Mar 1 2021 - 4:00pm to 7:00pm
Seyed Mahyad Aghigh
UBC Chemistry (Grant Group)
Mar 2 2021 - 12:45pm to 2:00pm
Yue Zhao
Département de Chimie - Université de Sherbrooke
Mar 4 2021 - 9:00am to 12:00pm
Elesha Hoffarth
UBC Chemistry (Ryan Group)


Headshots of Aakar and Jane, undergraduate award winners for the CIC Awards in Chemistry

Aakar Chatha and Jane Fu Receive CIC Awards in Chemistry

Aakar Chatha has won the CIC Second Year Award in Chemistry for his academic performance in second year chemistry courses. Jane Fu has wond the CIC Third Year Award in Chemistry for her academic performance in senior chemistry courses. Both were...

Headshot of Christopher Walters, winner of the new CGSS Prize in Science Outreach

Christopher Walters wins the new CGSS Prize in Science Outreach

We are pleased to announce Christopher Walters as the winner of the new Chemistry Graduate Student Society Prize in Science Outreach. The annual award is for Masters and Ph.D. students in the Department of Chemistry who have made contributions to...