|Title||2-Pyridonate Titanium Complexes for Chemoselectivity. Accessing Intramolecular Hydroaminoalkylation over Hydroamination|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Chong, E, Schafer, LL|
|Date Published||DEC 6|
Chemoselectivity of intramolecular hydroaminoalkylation over hydroamination has been achieved with a bis(3-phenyl-2-pyridonate) titanium complex. Primary aminoalkenes are selectively alpha-alkylated by C-H functionalization adjacent to nitrogen to access five- and six-membered cycloalkylamines with a good substrate-dependent diastereoselectivity of up to 19:1.