|Title||(55)Cobalt complexes with pendant carbohydrates as potential PET imaging agents|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Ferreira, CL, Lapi, S, Steele, J, Green, DE, Ruth, TJ, Adam, MJ, Orvig, C|
|Journal||Applied Radiation and Isotopes|
Bis-ligand cobalt(II) complexes of four 3-hydroxy-4-pyridinone ligands with pendant carbohydrates were synthesized and examined for their potential as radiopharmaceuticals. Non-radioactive complexes were prepared on the macroscopic scale and characterized by elemental analysis, mass spectrometry, IR and UV/visible spectroscopy. Facile radiolabeling produced the (CO)-C-55 complexes in high radiochemical yields (> 95%). Identification of the radiolabeled compounds was accomplished by HPLC comparison with the corresponding non-radioactive complexes. (c) 2007 Elsevier Ltd. All rights reserved.
|URL||<Go to ISI>://000251536900001|