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Arsenic speciation in human urine: are we all the same?

TitleArsenic speciation in human urine: are we all the same?
Publication TypeJournal Article
Year of Publication2004
AuthorsLai, VWM, Sun, YM, Ting, E, Cullen, WR, Reimer, KJ
JournalToxicology and Applied Pharmacology
Volume198
Pagination297-306
Date PublishedAug
Type of ArticleReview
ISBN Number0041-008X
Keywordsarsenic, arsenobetaine, arsenosugar, ENVIRONMENT, HPLC, ICP-MS, IDENTIFICATION, INGESTION, LIQUID-CHROMATOGRAPHY, MASS-SPECTROMETRY, METABOLITES, METHYLATED ARSENICALS, mussel, PRODUCTS, TRIVALENT, urine
Abstract

we studied the arsenic speciation in human urine samples by using high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS). We investigated the arsenic speciation in the urine collected from nine volunteers during a 3-day period after a meal of blue mussels, Mytilus edulis. We also studied the effect of cooking on the arsenic speciation. Arsenobetaine and dimethylarsinic acid (DMAA) were the major arsenic metabolites found in the urine samples. Significant amounts of unknown metabolites were also detected. The excretion patterns of arsenic from individuals were generally similar except for two subjects. One of whom excreted high amounts of arsenobetaine even though no arsenic-rich food was eaten for 3 days before the experiment. The results reveal that we need a better understanding of the metabolism of arsenic compounds by human. (C) 2004 Elsevier Inc. All rights reserved.

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