|Title||Catalytic alkyne hydrothiolation with alkanethiols using Wilkinson's catalyst|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Shoai, S, Bichler, P, Kang, B, Buckley, H, Love, JA|
|Date Published||NOV 19|
We recently discovered that Wilkinson's catalyst (ClRh(PPh3)(3)) is an excellent catalyst for alkyne hydrothiolation with alkanethiols to provide linear alkyl (E)-vinyl sulflides, which are valuable synthetic intermediates and precursors to bioactive molecules. Deuterium-labeling studies indicate that the reaction proceeds by thiol oxidative addition, alkyne migratory insertion, and subsequent reductive elimination.