|Title||Coordination chemistry and insulin-enhancing behavior of vanadium complexes with maltol C6H6O3 structural isomers|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Saatchi, K, Thompson, KH, Patrick, BO, Pink, M, Yuen, VG, McNeill, JH, Orvig, C|
|Type of Article||Article|
|Keywords||aluminum, BIS(MALTOLATO)OXOVANADIUM(IV), CRYSTAL-STRUCTURE, DIABETIC-RATS, ISOMALTOL, LIGANDS, REFINEMENT, SPECIATION, therapy, VANADATE|
Syntheses of vanadium complexes using the naturally occurring ligands isomaltol (Hima) and allomaltol (Hama), as well as a newly synthesized, potentially tetradentate diaminodipyrone [H-2(en(ama)(2)], are reported. Complete characterization of the resulting compounds [trans-VO(ima)(2)(H2O), VO(ama)(2), V(ima)(3), V(ama)(3) and VO(en(ama)(2))], including X-ray crystallography analyses for trans-VO(ima)(2)(H2O) and V(ima)3, are presented herein. Potentiometric titrations (25 degrees C, / = 0.16 M NaCl) were used to measure stability constants in the V(IV)-Hima system; these data were compared to previous data collected on the V(IV)-L (L = Hma, Hama) systems. The in vivo efficacy of these compounds to lower the blood glucose levels of STZ-diabetic rats was tested; all but VO(en(ama)2) produced significant decreases in plasma glucose levels. The results were compared to those of the benchmark compound BMOV [VO(ma)(2), bis(maltolato)oxovanadium(IV)], a known insulin-enhancing agent.
|URL||<Go to ISI>://000228374400019|