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Events

Domino Ring Opening Cyclization and Atom Transfer Radical Addition-Elimination

Date: 
Thursday, September 27, 2018 - 18:30 to 19:30
Speaker: 
Dr. Deo Tiwari
Affiliation: 
Bromme & Ciufolini Groups, Department of Chemistry, University of British Columbia
Event Category: 
ODG - Organic Discussion Group
Location: 
Chemistry D300

Abstract: 

Substituted chiral aziridines when reacted with active methylene compounds in the presence of catalytic amount of Lewis acid produced enantiomerically pure γ-lactams and dihydropyrroles via domino ring opening-cyclization. When Donor-Acceptor (DA)-cyclopropanes were taken as the substrate in place of aziridines, corresponding carbocyclic compounds were generated in diastereomerically pure form.

A new method for the synthesis of perfluoroalkenes via atom transfer radical addition-elimination under photoredox catalysis was also developed.