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Early transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines

TitleEarly transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines
Publication TypeJournal Article
Year of Publication2018
AuthorsEdwards, PM, Schafer, LL
JournalChem. Commun.
Volume54
Pagination12543-12560
Abstract

Hydroaminoalkylation is a 100% atom economic method for forming Csp3–Csp3 bonds through C–H activation α to an amine and subsequent reaction with an alkene. When catalyzed by early transition metals{,} this reaction allows for alternative disconnections for the synthesis of structurally complex amines. This method avoids the installation of protecting groups or directing groups and does not require added oxidants{,} or photoredox catalysts. In this feature article{,} we discuss the various selectively substituted amines that can be accessed by hydroaminoalkylation{,} with a special focus on the development of early transition metal catalysts for their rapid{,} step and atom efficient assembly.

URLhttp://dx.doi.org/10.1039/C8CC06445H
DOI10.1039/C8CC06445H