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Equations describing passive transport through vesicular membranes

TitleEquations describing passive transport through vesicular membranes
Publication TypeJournal Article
Year of Publication1998
AuthorsMales, RG, Phillips, PS, Herring, FG
JournalBiophysical Chemistry
Volume70
Pagination65-74
Date PublishedJan
Type of ArticleArticle
ISBN Number0301-4622
Keywordsaccumulation, DIFFUSION, FATTY-ACIDS, IONS, KINETICS, LARGE UNILAMELLAR VESICLES, lipid bilayer, LIPID BILAYER-MEMBRANES, LIPOSOMES, PARTITION-COEFFICIENTS, passive, permeability, PROCEDURE, RAPID EXTRUSION, TRANSMEMBRANE PH GRADIENTS, TRANSPORT
Abstract

A theoretical description of the kinetics of the passive transport of both lipophobic and lipophilic nonelectrolytes, weak acids, and weak bases through membranes of large unilamellar vesicles is discussed. Equations are derived which may be used to obtain permeability coefficients and predict the extent of LW entrapment of permeant molecules. Theoretical curves are generated to illustrate the difference between lipophobic and lipophilic permeation. By applying a diffusional approach rather than a simple first order kinetic approach to the problem of passive transport, some of the inconsistencies observed in other works are corrected. (C) 1998 Elsevier Science B.V.

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