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Exploration of the Scope of Pt-Catalyzed C-F Activation

TitleExploration of the Scope of Pt-Catalyzed C-F Activation
Publication TypeJournal Article
Year of Publication2011
AuthorsKeyes, L, Sun, AD, Love, JA
JournalEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Pagination3985-3994
Date PublishedJUL
ISSN1434-193X
Abstract

We recently reported methods for the catalytic methylation and methoxylation of polyfluoroaryl imines utilizing {[}Pt2Me4(SMe2)(2)] as a precatalyst. These methodologies provide a novel route to partially functionalized aryl fluorides, which have potential utility as building blocks for the synthesis of pharmaceuticals and materials. We report herein efforts to expand the scope of these processes, particularly the choice of directing group. Comparisons to the previously reported scope of Pt-II-catalyzed methylation and methoxylation are described.

DOI10.1002/ejoc.201100478