The observation that the incorporation of fluorine into drugs often leads to significantly improved medicinal properties has revolutionized the development of pharmaceuticals. Indeed, there were no fluorinated medicaments on the market in 1957, while today more than 20% of medicinal compounds contain fluorine. The development of new synthetic technologies for the selective fluorination of organic compounds has increased with the escalating importance of fluorine-containing pharmaceuticals. The first part of this talk will focus the evolution of our approach to fluorination, from our early work on fluorine atom transfer agents, to our studies on single electron transfer fluorination processes. The second part will focus on the application of sulfuryl fluoride as a reagent for the one-pot installation of fluorinated motifs and how sulfuryl fluoride can be used as a general, and effective activating agent. New advances in sulfur fluoride reagents will also be discussed.