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Ion fragmentation in an electrospray ionization mass spectrometer interface with different gases

TitleIon fragmentation in an electrospray ionization mass spectrometer interface with different gases
Publication TypeJournal Article
Year of Publication2001
AuthorsSchneider, BS, Douglas, DJ, Chan, DDY
JournalRapid Communications in Mass Spectrometry
Volume15
Pagination249-257
Type of ArticleArticle
ISBN Number0951-4198
KeywordsCONDENSATION, FREE-JET EXPANSIONS, INDUCED DISSOCIATION, LIQUID-HELIUM CLUSTERS, MYOGLOBIN, PERFORMANCE, PROTEIN IDENTIFICATION, SPECTROSCOPY, TECHNOLOGY, TEMPERATURE
Abstract

Nitrogen, argon, and krypton are used as curtain gases in an electrospray ionization mass spectrometer in an attempt to study the effect of these gases on the extent of ion fragmentation between the orifice and the skimmer of the interface region. A previously published collision model predicts that the degree of ion fragmentation increases with increasing mass of the curtain gas. However, the fragmentation yields are found to be the opposite to that expected. It is believed that the reversed trend with argon and krypton is caused by condensation of the gases within the free jet expansion between the orifice and the skimmer. A condensation parameter can be used to predict the degree of clustering of gases within a free jet expansion. When the condensation parameter is minimized, the predicted trend of fragmentation with mass is observed. Copyright (C) 2001 John Wiley & Sons, Ltd.

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