Keng Chou

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Keng Chou

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Research and Teaching Interests

Major Research Interests:

(I) Super-resolution Microscopy

     We develop high-resolution optical microscopes to study biological problems. The resolution of optical microscopy has been limited to ~ 200 nm because of the diffraction limit. Recent developments in super-resolution microscopy has enabled scientists to resolve features as small as 10 nm and visualize cellular structures in unprecedented detail. Our current research is focused on virus-host interactions.

Selected publications:

  • Liu, Q. ; Chen, L. ; Aguilar, H. C. ; Chou, K. C. "A Stochastic Assembly Model for Nipah Virus Revealed by Super-Resolution Microscopy", Nature Communications, 9, 3050 (2018)
  • Tafteh, R. ; Abraham, L. ; Seo, D. ; Lu, H. Y. ; Gold, M. R. ; Chou, K. C. "Real-Time 3D Stabilization Of a Super-Resolution Microscope Using an Electrically Tunable Lens", Optics Express, 24, 22959-22970 (2016)

Related link: Biomedical Imaging and Artificial Intelligence
 

(II)  Surface Properties of Water

     Water has a relatively simple molecular structure, but the water interface is a very complex system. We study water interfaces relevant to environmental and industrial applications using nonlinear optical spectroscopy.

Selected publications:

  • "Transient Phase of Ice Observed by Sum Frequency Generation at the Water/Mineral Interface During Freezing", K. A. Lovering, A. K. Bertram, and K. C. Chou, Journal of Physical Chemistry Letters, 8 (4), 871 –875 (2017)
  • "Complex Formations Between Surfactants and Polyelectrolytes of The Same Charge on a Water Surface", Mafi, A. ; Hu, D. ; Chou, K. C., Langmuir, 33, 7940-7946 (2017)
  • "Revisit the Thermodynamics of Water Surface in the Presence of Surfactants", D. Hu, A. Mafia, K. C. Chou, Journal of Physical Chemistry B, 120 (9), 2257–2261 (2016)
  • "Re-evaluating the Surface Tension Analysis of Polyelectrolyte-Surfactant Mixtures Using Phase-sensitive Sum Frequency Generation Spectroscopy", D. Hu and K. C. Chou, Journal of the American Chemical Society (Communication),136 (43), 15114 (2014)
  • “Why Do Sulfuric Acid Coatings Influence the Ice Nucleation Properties of Mineral Dust Particles in the Atmosphere?”, Z. Yang, A. K. Bertram, and K. C. Chou, Journal of Physical Chemistry Letters, 2, 1232–1236 (2011)

 

(III) Petroleum Surface Chemistry

     Canada’s oil sands reserves, which are estimated at 175 billion barrels, place Canada second in the world ranking of crude oil reserves. However, the large amount of water used in current bitumen extraction processes is a great concern, particularly as the industry is expected to grow over the next 20 years. Our research objective is to understand the competition adsorption of solvents, water, and bitumen on mineral materials to provide molecular-level information for developing a more environment-friendly extraction process. This research project has been funded by the Institute for Oil Sands Innovation located in the University of Alberta.

Selected publications:

  • Yang, Z. ; Nikakhtari, H. ; Wolf, S. ; Hu, D. ; Gray, M. R. ; Chou, K. C. "Binary Solvents With Ethanol For Effective Bitumen Displacement At Solvent/mineral Interfaces", Energy & Fuels, 29 (7), 4222–4226 (2015)
  • Hu, D. ; Chou, K. C. "Surface Charge At The Bitumen/water Interface Investigated By Phase-Sensitive Sum Frequency Generation Vibrational Spectroscopy: Effects Of Ph, Ions, And Surfactants", Energy & Fuels, 29, 7885-7888 (2015)

Related link: Institute for Oil Sands Innovation

 

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Contact

Real name: 
Email: 
Office Room Number(s): 
D348
Office Phone Number: 
604-822-5850
Fax Number: 
604-822-2847

Curriculum Vitae

2004-: Department of Chemistry, University of British Columbia;

2001-2004: Department of Chemistry, University of California, Berkeley (postdoctoral study in surface chemistry);

1994-2001: Department of Physics, University of California, Riverside (graduate study in condensed matter physics);

1993-1994: Department of Physics, Brown University (graduate study in particle physics);

1992,1993: L3 ExperimentEuropean Organization for Nuclear Research (Research Assistant in particle physics);

1991-1993: Department of Physics, National Central University (graduate study in particle physics; MSc, 1994);

1985-1989: Department of Physics, Tunghai University (BS, 1989)

Publications

2018

Choi, J. R. ; Nilghaz, A. ; Chen, L. ; Chou, K. C. ; Lu, X. N. Modification Of Thread-Based Microfluidic Device With Polysiloxanes For The Development Of A Sensitive And Selective Immunoassay. Sensors and Actuators B-Chemical 2018, 260, 1043-1051.
Han, Y. ; Chen, L. ; Liu, Y. G. ; Wang, Z. ; Zhang, H. W. ; Yang, K. ; Chou, K. C. Orbital Angular Momentum Transition Of Light Using A Cylindrical Vector Beam. Optics Letters 2018, 43, 2146-2149.
Lovering, K. A. ; Chou, K. C. Insights Into Ice Formation Via Immersion Freezing From Nonlinear Optical Spectroscopy. Topics in Catalysis 2018, 61, 1163-1168.
Mafi, A. ; Abbina, S. ; Kalathottukaren, M. T. ; Morrissey, J. H. ; Haynes, C. ; Kizhakkedathu, J. N. ; Pfaendtner, J. ; Chou, K. C. Design Of Polyphosphate Inhibitors: A Molecular Dynamics Investigation On Polyethylene Glycol-Linked Cationic Binding Groups. Biomacromolecules 2018, 19, 1358-1367.
Liu, Q. ; Chen, L. ; Aguilar, H. C. ; Chou, K. C. A Stochastic Assembly Model For Nipah Virus Revealed By Super-Resolution Microscopy. Nature Communications 2018, 9.
Chen, L. ; Han, Y. ; Liu, Q. ; Liu, Y. G. ; Zhang, W. G. ; Chou, K. C. Microcavity-Coupled Fiber Bragg Grating With Tunable Reflection Spectra And Speed Of Light. Optics Letters 2018, 43, 1662-1665.

2017

Lovering, K. A. ; Bertram, A. K. ; Chou, K. C. Transient Phase Of Ice Observed By Sum Frequency Generation At The Water/mineral Interface During Freezing. Journal of Physical Chemistry Letters 2017, 8, 871-875.

2016

Chen, L. ; Liu, Q. ; Zhang, W. G. ; Chou, K. C. Ringing Phenomenon In Chaotic Microcavity For High-Speed Ultra-Sensitive Sensing. Scientific Reports 2016, 6.
Chen, L. ; Qu, K. N. ; Shen, H. ; Zhang, W. G. ; Chou, K. C. ; Liu, Q. ; Yan, T. Y. ; Wang, B. ; Wang, S. In-Line Polarization Rotator Based On The Quantum-Optical Analogy. Optics Letters 2016, 41, 2113-2116.
Hu, D. ; Mafi, A. ; Chou, K. C. Revisiting The Thermodynamics Of Water Surfaces And The Effects Of Surfactant Head Group. Journal of Physical Chemistry B 2016, 120, 2257-2261.
Lovering, K. A. ; Bertram, A. K. ; Chou, K. C. New Information On The Ion-Identity-Dependent Structure Of Stern Layer Revealed By Sum Frequency Generation Vibrational Spectroscopy. Journal of Physical Chemistry C 2016, 120, 18099-18104.
Mafi, A. ; Hu, D. ; Chou, K. C. Interactions Of Sulfobetaine Zwitterionic Surfactants With Water On Water Surface. Langmuir 2016, 32, 10905-10911.
Tafteh, R. ; Abraham, L. ; Seo, D. ; Lu, H. Y. ; Gold, M. R. ; Chou, K. C. Real-Time 3D Stabilization Of A Super-Resolution Microscope Using An Electrically Tunable Lens. Optics Express 2016, 24, 22959-22970.
Tafteh, R. ; Scriven, D. R. L. ; Moore, E. D. W. ; Chou, K. C. Single Molecule Localization Deep Within Thick Cells; A Novel Super-Resolution Microscope. Journal of Biophotonics 2016, 9, 155-160.

2015

Yang, Z. ; Nikakhtari, H. ; Wolf, S. ; Hu, D. ; Gray, M. R. ; Chou, K. C. Binary Solvents With Ethanol For Effective Bitumen Displacement At Solvent/mineral Interfaces. Energy & Fuels 2015.
Tafteh, R. ; Scriven, D. R. L. ; Moore, E. D. W. ; Chou, K. C. Single Molecule Localization Deep Within Thick Cells; A Novel Super-Resolution Microscope. Journal of Biophotonics 2015.
Tsou, C. J. ; Hsia, C. H. ; Chu, J. Y. ; Hung, Y. ; Chen, Y. P. ; Chien, F. C. ; Chou, K. C. ; Chen, P. L. ; Mou, C. Y. Local Ph Tracking In Living Cells. Nanoscale 2015, 7, 4217-4225.

2014

Shih, J. - Y. ; Huang, W. - C. ; Ko, C. - T. ; Yang, Z. ; Hu, S. - H. ; Leu, J. ; Chou, K. C. ; Chen, K. - N. Adhesion Investigation Between Metal And Benzocyclobutene (Bcb) Polymer Dielectric Materials In 3-D Integration Applications. Ieee Transactions on Device and Materials Reliability 2014, 14, 914-920.

2013

Leung, J. P. ; Wu, S. ; Chou, K. C. ; Signorell, R. Investigation Of Sub-100 Nm Gold Nanoparticles For Laser-Induced Thermotherapy Of Cancer. Nanomaterials 2013, 3, 86-106.

2012

Leung, B. O. ; Yang, Z. ; Wu, S. S. H. ; Chou, K. C. Role Of Interfacial Water On Protein Adsorption At Cross-Linked Polyethylene Oxide Interfaces. Langmuir 2012, 28, 5724-5728.

2011

Leung, B. O. ; Chou, K. C. Review Of Super-Resolution Fluorescence Microscopy For Biology. Applied Spectroscopy 2011, 65, 967-980.
Yang, Z. ; Bertram, A. K. ; Chou, K. C. Why Do Sulfuric Acid Coatings Influence The Ice Nucleation Properties Of Mineral Dust Particles In The Atmosphere?. Journal of Physical Chemistry Letters 2011, 2, 1232-1236.

2010

Yang, Z. ; Li, Q. ; Gray, M. R. ; Chou, K. C. Structures Of Water Molecules At Solvent/silica Interfaces. Langmuir 2010, 26, 16397-16400.

2009

Yang, Z. ; Li, Q. F. ; Hua, R. ; Gray, M. R. ; Chou, K. C. Competitive Adsorption Of Toluene And N-Alkanes At Binary Solution/silica Interfaces. Journal of Physical Chemistry C 2009, 113, 20355-20359.
Yang, Z. ; Li, Q. F. ; Chou, K. C. Structures Of Water Molecules At The Interfaces Of Aqueous Salt Solutions And Silica: Cation Effects. Journal of Physical Chemistry C 2009, 113, 8201-8205.
Li, Q. F. ; Wu, S. S. H. ; Chou, K. C. Subdiffraction-Limit Two-Photon Fluorescence Microscopy For Gfp-Tagged Cell Imaging. Biophysical Journal 2009, 97, 3224-3228.
Li, Q. F. ; Kuo, C. W. ; Yang, Z. ; Chen, P. L. ; Chou, K. C. Surface-Enhanced Ir-Visible Sum Frequency Generation Vibrational Spectroscopy. Physical Chemistry Chemical Physics 2009, 11, 3436-3442.
Weiss, A. ; Preston, T. C. ; Popov, J. ; Li, Q. ; Wu, S. ; Chou, K. C. ; Burt, H. M. ; Bally, M. B. ; Signorell, R. Selective Recognition Of Rituximab-Functionalized Gold Nanoparticles By Lymphoma Cells Studied With 3D Imaging. Journal of Physical Chemistry C 2009, 113, 20252-20258.

2008

Pietrangelo, A. ; Sih, B. C. ; Boden, B. N. ; Wang, Z. W. ; Li, Q. F. ; Chou, K. C. ; MacLachlan, M. J. ; Wolf, M. O. Nonlinear Optical Properties Of Schiff-Base-Containing Conductive Polymer Films Electro-Deposited In Microgravity. Advanced Materials 2008, 20, 2280-+.
Li, Q. F. ; Hua, R. ; Cheah, I. J. ; Chou, K. C. Surface Structure Relaxation Of Poly(Methyl Methacrylate). Journal of Physical Chemistry B 2008, 112, 694-697.

2005

Stamenkovic, V. ; Chou, K. C. ; Somorjai, G. A. ; Ross, P. N. ; Markovic, N. M. Vibrational Properties Of Co At The Pt(111)-Solution Interface: The Anomalous Stark-Tuning Slope. Journal of Physical Chemistry B 2005, 109, 678-680.

2004

Westerberg, S. ; Wang, C. ; Chou, K. ; Somorjai, G. A. High-Pressure Ammonia Adsorption And Dissociation On Clean Fe(111) And Oxygen-Precovered Fe(111) Studied By Sum Frequency Generation Vibrational Spectroscopy. Journal of Physical Chemistry B 2004, 108, 6374-6380.
Chou, K. C. ; Westerberg, S. ; Shen, Y. R. ; Ross, P. N. ; Somorjai, G. A. Probing The Charge-Transfer State Of Co On Pt(111) By Two-Dimensional Infrared-Visible Sum Frequency Generation Spectroscopy. Physical Review B 2004, 69.

2003

Kim, J. ; Chou, K. C. ; Somorjai, G. A. Structure And Dynamics Of Acetonitrile At The Air/liquid Interface Of Binary Solutions Studied By Infrared-Visible Sum Frequency Generation. Journal of Physical Chemistry B 2003, 107, 1592-1596.
Chou, K. C. ; Kim, J. ; Baldelli, S. ; Somorjai, G. A. Vibrational Spectroscopy Of Carbon Monoxide, Acetonitrile, And Phenylalanine Adsorbed On Liquid Vertical Bar Electrode Interfaces By Sum Frequency Generation. Journal of Electroanalytical Chemistry 2003, 554, 253-263.
Chou, K. C. ; Markovic, N. M. ; Kim, J. ; Ross, P. N. ; Somorjai, G. A. An In Situ Time-Dependent Study Of Co Oxidation On Pt(111) In Aqueous Solution By Voltammetry And Sum Frequency Generation. Journal of Physical Chemistry B 2003, 107, 1840-1844.

2002

Hoffer, S. ; Baldelli, S. ; Chou, K. ; Ross, P. ; Somorjai, G. A. Co Oxidation On Electrified Platinum Surfaces In Acetonitrile/water Solutions Studied By Sum Frequency Generation And Cyclic Voltammetry. Journal of Physical Chemistry B 2002, 106, 6473-6478.

1999

Kwak, H. ; Chou, K. C. ; Guo, J. ; Tom, H. W. K. Femtosecond Laser-Induced Disorder Of The (1 X 1)-Relaxed Gaas(110) Surface. Physical Review Letters 1999, 83, 3745-3748.