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Kinetic analysis and comparison of uptake, distribution, and excretion of V-48-labeled compounds in rats

TitleKinetic analysis and comparison of uptake, distribution, and excretion of V-48-labeled compounds in rats
Publication TypeJournal Article
Year of Publication1998
AuthorsSetyawati, IA, Thompson, KH, Yuen, VG, Sun, Y, Battell, M, Lyster, DM, Vo, C, Ruth, TJ, Zeisler, S, McNeill, JH, Orvig, C
JournalJournal of Applied Physiology
Volume84
Pagination569-575
Date PublishedFeb
Type of ArticleArticle
ISBN Number8750-7587
KeywordsADIPOCYTES, analysis, and modeling, BIS(MALTOLATO)OXOVANADIUM(IV), compartmental modeling, diabetes, DISSOCIATION, FERRIC MALTOL, GLUCOSE, INDUCED DIABETIC RATS, INSULIN, insulin mimetic, METABOLISM, MOLYBDENUM, SIMULATION, SMALL-INTESTINE, Software, VANADIUM, VANADYL SULFATE
Abstract

Vanadium has been found to be orally active in lowering plasma glucose levels; thus it provides a potential treatment for diabetes mellitus. Bis(maltolato)oxovanadium(rv) (BMOV) is a well-characterized organovanadium compound that has been shown in preliminary studies to have a potentially useful absorption profile. Tissue distributions of BMOV compared with those of vanadyl sulfate (VS) were studied in Wistar rats by using V-48 as a tracer. In this study, the compounds were administered in carrier-added forms by either oral gavage or intraperitoneal injection. Data analyzed by a compartmental model, by using simulation, analysis, and modeling (i.e., SAAM II) software, showed a pattern of increased tissue uptake with use of V-48-BMOV compared with (VS)-V-48. The highest V-48 concentrations at 24 h after gavage were in bone, followed by kidney and liver. Most ingested V-48 was eliminated unabsorbed by fecal excretion. On average, V-48 concentrations in bone, kidney, and liver 24 h after oral administration of V-48-BMOV were two to three times higher than those of (VS)-V-48, which is consistent with the increased glucose-lowering potency of BMOV in acute glucose lowering compared with VS.

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