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Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: Comparison with cationic antimicrobial peptides and lipopeptides

TitleMode of action of the new antibiotic for Gram-positive pathogens daptomycin: Comparison with cationic antimicrobial peptides and lipopeptides
Publication TypeJournal Article
Year of Publication2006
AuthorsStraus, SK, Hancock, REW
JournalBiochimica Et Biophysica Acta-Biomembranes
Volume1758
Pagination1215-1223
Date PublishedSep
Type of ArticleReview
ISBN Number0005-2736
KeywordsBACTERICIDAL ACTIVITY, cationic peptide, Daptomycin, ENTEROCOCCUS-FAECIUM, FATTY-ACID, Gram-positive pathogen, INVITRO ACTIVITY, LIPID-BILAYER DISRUPTION, lipopeptide, LY146032 DAPTOMYCIN, mechanism of action, POLYMYXIN-B, SOLID-STATE NMR, STAPHYLOCOCCUS-AUREUS, VALVE ENDOCARDITIS
Abstract

With the steady rise in the number of antibiotic-resistant Gram-positive pathogens, it has become increasingly important to find new antibacterial agents which are highly active and have novel and diversified mechanisms of action. Two classes will be discussed here: the cationic antimicrobial peptides, which are amphiphilic in nature, targeting membranes and increasing their permeability; and lipopeptides, which consist of linear or cyclic peptides with an N-terminus that is acylated with a fatty acid side chain. One member of the cyclic lipopeptide family, the anionic molecule daptomycin, has been extensively studied and is the major focus of this review. Models will be presented on its mode of action and comparisons will be made to the known modes of action of cationic antimicrobial peptides and other lipopeptides. (c) 2006 Elsevier B.V. All rights reserved.

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