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Nickel-Catalyzed Selective Defluorination to Generate Partially Fluorinated Biaryls

TitleNickel-Catalyzed Selective Defluorination to Generate Partially Fluorinated Biaryls
Publication TypeJournal Article
Year of Publication2011
AuthorsSun, AD, Love, JA
JournalORGANIC LETTERS
Volume13
Pagination2750-2753
Date PublishedMAY 20
ISSN1523-7060
Abstract

A Ni-catalyzed, chemoselective cross-coupling reaction of polyfluoroarenes under mild reaction conditions is reported. A variety of fluorine-containing blaryls are synthesized in good-to-excellent yields. A wide range of substitution patterns and functional groups are tolerated.

DOI10.1021/ol200860t