Congratulations to the Sammis Lab group!
The Sammis Lab groups most recent paper, Single-Electron/Pericyclic Cascade for the Synthesis of Dienes, has been featured in Angewandte Chemie International Edition. According to their Editor, it is being described as “hot paper” status.
The highly efficient and diastereoselective synthesis of E dienes has been accomplished through radical cyclization of bromoallyl hydrazones. This methodology has been further extended to generate these products through a one-pot condensation/radical cyclization/cycloreversion cascade from simple aldehyde starting materials in high yields (>75 %) and high diastereoselectivities (>95:5). Mechanistic investigations suggest that the cascade reaction proceeds through a cyclic diazene intermediate prior to the cycloreversion.