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Stereocontrolled construction of the A-ring of nitiol using a Pauson-Khand cycloaddition-ring fragmentation strategy

TitleStereocontrolled construction of the A-ring of nitiol using a Pauson-Khand cycloaddition-ring fragmentation strategy
Publication TypeJournal Article
Year of Publication2001
AuthorsWilson, MS, Dake, GR
JournalOrganic Letters
Volume3
Pagination2041-2044
Date PublishedJun
Type of ArticleArticle
ISBN Number1523-7060
KeywordsACID, ACTIVE BICYCLO<3.3.0>OCTENONE DERIVATIVES, ALDER, ALKENE ALKYNE CYCLIZATIONS, ENZYME-CATALYZED-HYDROLYSIS, NATURAL-PRODUCTS
Abstract

[GRAPHICS] A stereocontrolled construction of the A-ring of nitiol (1) is presented, Key features in this approach are a diastereoselective Pauson-Khand cycloaddition and a Norrish type 1 fragmentation reaction.
URL<Go to ISI>://000169487700020