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Strategies and Methods for Chemical Synthesis Inspired by Natural Products

Date: 
Tuesday, September 18, 2018 - 12:45 to 14:00
Speaker: 
Dr. Richmond Sarpong I Distinguished Organic Lecture
Affiliation: 
Department of Chemistry, University of California, Berkeley
Event Category: 
LMC - Lectures in Modern Chemistry
Location: 
Chemistry B250

Abstract:

Natural products continue to inspire and serve as the basis of new medicines. They also provide intricate problems that expose limitations in the strategies and methods employed in chemical synthesis. Several strategies and methods that have been developed in our laboratory and applied to the syntheses of architecturally complex diterpenoid alkaloids, indole alkaloids, and several Lycopodium alkaloids, will be discussed. In addition, new ways to employ C–C bond cleavage in synthesis will be presented.

 

[1] Marth, C.J.; Gallego, G.M.; Lee, J.C.; Lebold, T.P.; Kulyk, S.; Kou, K.G.M.; Qin, J.; Lilien, R.; Sarpong, R.; Nature 2015, 528, 493.

[2] Mercado-Marin, E.V.; Garcia-Reynaga, P.; Romminger, S.; Pimenta, E.F.; Romney, D.K.; Lodewyk, M.W.; Williams, D.E.; Andersen, R.J.; Miller, S.J.; Tantillo, D.J.; Berlinck, R.G.S.; Sarpong, R.; Nature 2014, 509, 318.

[3] Roque, J. B.; Kuroda, Y.; Göttemann, L. T.; Sarpong, R. Science, 2018 (In Press)