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Use of NMR imaging in the optimization of a compression-coated regulated release system

TitleUse of NMR imaging in the optimization of a compression-coated regulated release system
Publication TypeJournal Article
Year of Publication1998
AuthorsFahie, BJ, Nangia, A, Chopra, SK, Fyfe, CA, Grondey, H, Blazek, A
JournalJournal of Controlled Release
Volume51
Pagination179-184
Date PublishedFeb
Type of ArticleArticle
ISBN Number0168-3659
Keywordscompression coating, DIFFUSION, formulation optimization, modified-release tablet, NMR imaging, POLYMERS, regulated-release tablet, RODS
Abstract

Nuclear magnetic resonance (NMR) imaging is routinely used to detect the protons of mobile water molecules within samples. In this investigation, this non-destructive, non-invasive technique was used to determine the cause for faster than predicted drug release from a dissolution-based regulated-release tablet. The NMR images of tablets, from mio different formulations, taken at various intervals of time while immersed in static USP dissolution medium showed that the tablet with faster than predicted drug release had a porous coating. The porous coat exposed more of the core surface area to the dissolution medium than desired and this caused an increase in the rate of dissolution of the core. The data presented in this paper demonstrate the usefulness of NMR imaging in solid dosage form development. (C) 1998 Elsevier Science B.V.

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