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Utilization of (p, 4n) reaction for 86Zr production with medium energy protons and development of a 86Zr → 86Y radionuclide generator

TitleUtilization of (p, 4n) reaction for 86Zr production with medium energy protons and development of a 86Zr → 86Y radionuclide generator
Publication TypeJournal Article
Year of Publication2018
AuthorsBaimukhanova, A, Radchenko, V, Kozempel, J, Marinova, A, Brown, V, Karandashev, V, Karaivanov, D, Schaffer, P, Filosofov, D
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume316
Pagination191–199
Date PublishedApr
ISSN1588-2780
Abstract

Utilization of (p, 4n) reaction channel for the production of medical radionuclides became very attractive with commercial availability of medium energy cyclotrons. Significantly higher yields and radionuclidic purity may open new perspectives for several novel and some of the radionuclides previously have not been considered due to production difficulties. In present work, we show the proof-of-principle study on the production of 86Y for Positron Emission Tomography imaging via radionuclide generator 86Zr → 86Y. Production suitability of 86Zr from natural yttrium target and radiochemical separation strategies were tested. In addition, two generator systems were proposed and evaluated.

URLhttps://doi.org/10.1007/s10967-018-5730-7
DOI10.1007/s10967-018-5730-7