Uncovering How Negamycin Is Made: Key Enzymes Behind a Promising Antibiotic and Genetic Disease Treatment
Negamycin is a powerful antibiotic that may also help treat genetic diseases. Prof Katherine Ryan and her research group have found it’s made using two special enzymes: one (NegB) makes a rare form of lysine, and another (NegJ) creates a unique nitrogen–nitrogen bond, helping build the drug and guiding the search for similar compounds.