@article {1093,
	title = {Interaction of alamethicin with ether-linked phospholipid bilayers: Oriented circular dichroism, P-31 solid-state NMR, and differential scanning calorimetry studies},
	journal = {Biophysical Journal},
	volume = {89},
	number = {4},
	year = {2005},
	note = {ISI Document Delivery No.: 968FPTimes Cited: 22Cited Reference Count: 60},
	month = {Oct},
	pages = {2434-2442},
	type = {Article},
	abstract = {The arrangement of the antimicrobial peptide alamethicin was studied by oriented circular dichroism, 31 P solidstate NMR, and differential scanning calorimetry in ether- linked phospholipid bilayers composed of 1,2-O-dihexadecyl- sn-glycero3- phosphocholine ( DHPC). The measurements were performed as a function of alamethicin concentration relative to the lipid concentration, and results were compared to those reported in the literature for ester-linked phospholipid bilayers. At ambient temperature, alamethicin incorporates into the hydrophobic core of DHPC bilayers but results in more lipid disorder than observed for ester-linked 1-palmitoyl, 2-oleoyl-sn-glycero-3-phosphatidylcholine ( POPC) lipid bilayers. This orientational disorder appears to depend on lipid properties such as bilayer thickness. Moreover, the results suggest that alamethicin inserts into the hydrophobic core of the bilayers ( at high peptide concentration) for both ether- and ester-linked lipids but using a different mechanism, namely toroidal for DHPC and barrel-stave for POPC.},
	keywords = {BIOLOGICAL-MEMBRANES, CYTOCHROME-C, DIPHYTANOYL PHOSPHATIDYLCHOLINE, FUSION PEPTIDES, HYDROPHOBIC MISMATCH, LIPID-BILAYER, MOLECULAR-DYNAMICS SIMULATIONS, NUCLEAR-MAGNETIC-RESONANCE, THERMOTROPIC PHASE-BEHAVIOR, X-RAY-DIFFRACTION},
	isbn = {0006-3495},
	url = {<Go to ISI>://000232147600025},
	author = {Dave, P. C. and Billington, E. and Pan, Y. L. and Straus, S. K.}
}
