@article {9839,
	title = {In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer{\textquoteright}s disease.},
	journal = {Dalton Transactions},
	volume = {39},
	year = {2010},
	note = {CAPLUS AN 2010:112638(Journal)},
	month = {2010///},
	pages = {1604 - 1615},
	publisher = {Royal Society of Chemistry},
	abstract = {Glycosides of 3-hydroxy-4-pyridinones were synthesized and characterized by mass spectrometry, elemental anal., 1H and 13C NMR spectroscopy, and in one case by X-ray crystallog. The Cu2+ complex of a novel 3-hydroxy-4-pyridinone was synthesized and characterized by IR and X-ray crystallog., showing the ability of these compds. to chelate potentially toxic metal ions. An MTT cytotoxicity assay of a selected glycosylated compd. showed a relatively low toxicity of IC50 = 570 {\textpm} 90 μM in a human breast cancer cell line. The pyridinone glycosides could be cleaved by a broad specificity beta-glycosidase, Agrobacterium sp.β-glucosidase, and for one compd. kcat and Km were detd. to be 19.8 s-1 and 1.52 mM, resp. Trolox Equiv. Antioxidant Capacity (TEAC) values were detd. for the free pyridinones, indicating the good antioxidant properties of these compds. Metal-Aβ1-40 aggregates with zinc and copper were resolubilized by the non-glycosylated pyridinone ligands. [on SciFinder(R)]},
	keywords = {hydroxypyridinone Alzheimers disease},
	isbn = {1477-9226},
	author = {Green,David E. and Bowen,Meryn L. and Scott,Lauren E. and Storr,Tim and Merkel,Michael and Boehmerle,Karin and Thompson,Katherine H. and Patrick,Brian O. and Schugar,Harvey J. and Orvig, Chris}
}
