@article {1219,
	title = {Synthesis and insulin-mimetic activities of metal complexes with 3-hydroxypyridine-2-carboxylic acid},
	journal = {Journal of Inorganic Biochemistry},
	volume = {99},
	number = {6},
	year = {2005},
	note = {ISI Document Delivery No.: 934IJTimes Cited: 16Cited Reference Count: 28},
	month = {Jun},
	pages = {1275-1282},
	type = {Article},
	abstract = {Metal complexes of 3-hydroxypyridine-2-carboxylic acid (H(2)hpic), [Co(Hhpic)(2)(H2O)(2)] (1), [Fe(Hhpic)(2)(H2O)(2)] (2), [Zn(Hhpic)(2)(H2O)(2)] (3), [Mn(Hhpic)(2)(H2O)(2)] (4), and [Cu(Hhpic)(2)] (5) have been synthesized and characterized by mass spectrometry, elemental analysis, magnetic susceptibility, infrared, electronic absorption and electron paramagnetic resonance (EPR) spectroscopies. The solid-state structure of 1 has been established by X-ray crystallography. The EPR spectra of 4 and 5 displayed six and four-line hyperfine splitting patterns, respectively, due to coupling of the unpaired electron with the Mn-55 (I=5/2) nucleus and the Cu-63 (I=3/2) nucleus. In the EPR spectrum of 5, an additional five-line super-hyperfine splitting pattern was observed at 77 K, caused by additional interaction of the unpaired electron with ligand nitrogen atoms (I=1), indicating that the structure of 5 was retained in dimethyl sulfoxide solution. The insulin-mimetic activity of these complexes was evaluated by means of in vitro measurements of the inhibition of free fatty acid (FFA) release from epinephrine-treated, isolated rat adipocytes. Complex 5 was found to exhibit the most potent insulin-mimetic activity among the complexes examined in this study. (C) 2005 Elsevier Inc. All rights reserved.},
	keywords = {3-hydroxypyridine-2-carboxylic acid (H(2)hpic), CHEMISTRY, DIABETIC-RATS, GLUCOSE, insulin-mimetic drug, MECHANISM, MONONUCLEAR, RAT ADIPOCYTES, VANADIUM},
	isbn = {0162-0134},
	url = {<Go to ISI>://000229702200002},
	author = {Nakai, M. and Sekiguchi, F. and Obata, M. and Ohtsuki, C. and Adachi, Y. and Sakurai, H. and Orvig, Chris and Rehder, D. and Yano, S.}
}
