@article {758,
	title = {Boon and bane of metal ions in medicine},
	journal = {Science},
	volume = {300},
	number = {5621},
	year = {2003},
	note = {ISI Document Delivery No.: 675WDTimes Cited: 99Cited Reference Count: 30},
	month = {May},
	pages = {936-939},
	type = {Review},
	abstract = {In biological systems metal ions promote responses that range from deficiency to toxicity. Some, such as iron and zinc, have a known optimal intake range for normal, healthy individuals. Metal ions contained within well-designed molecules already constitute a great boon for the medicinal pharmacopoeia. However, whether essential or not, the threshold for toxicity can be very low. One of the challenges of designing metal-based drugs is to balance the potential toxicity of an active formulation with the substantial positive impact of these increasingly common therapeutic and diagnostic aids.},
	keywords = {AGENTS, COMPLEXES, RADIOPHARMACEUTICALS},
	isbn = {0036-8075},
	url = {<Go to ISI>://000182719800043},
	author = {Thompson, K. H. and Orvig, Chris}
}
