@article { ISI:000280861300031,
	title = {Pulling Genetic RNA out of Tobacco Mosaic Virus Using Single-Molecule Force Spectroscopy},
	journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},
	volume = {132},
	number = {32},
	year = {2010},
	month = {AUG 18},
	pages = {11036-11038},
	abstract = {RNA-coat protein interactions in intact tobacco mosaic virus have been investigated for the first time directly on the single-molecule level by pulling the genetic RNA step by step out of the helical groove formed by its protein coat. The effects of pulling speed and pH on RNA-protein interactions are presented. In addition, the rebinding behavior of the detached RNA with the protein coat is discussed. Our results demonstrate the possibility of studying nucleic acid-protein interactions in more complicated systems using AFM-based single-molecule force spectroscopy.},
	issn = {0002-7863},
	doi = {10.1021/ja1052544},
	author = {Liu, Ningning and Peng, Bo and Lin, Yuan and Su, Zhaohui and Niu, Zhongwei and Wang, Qian and Zhang, Wenke and Li, Hongbin and Shen, Jiacong}
}
