@article { ISI:000168026000009, title = {Synthesis of 2,6-dideoxy-2-fluoro-6-{[}F-18]-fluoro-beta-D-glucopyranosyl fluoride (2,6FGF) as a potential imaging probe for glucocerebrosidase}, journal = {JOURNAL OF LABELLED COMPOUNDS \& RADIOPHARMACEUTICALS}, volume = {44}, number = {5}, year = {2001}, month = {APR}, pages = {385-394}, abstract = {We have previously synthesized 2-deoxy-2-{[}F-18]-fluoro-beta -mannosyl {[}F-18]-fluoride and shown that it behaves as a mechanism-based inhibitor of Agrobacterium sp. beta -glucosidase. In-vivo experiments indicate that this compound undergoes partial hydrolysis to produce 2-deoxy-2-fluoro-mannose, which can become phosphorylated and trapped within the cell. We now report the synthesis of another 2-fluoro glycoside which is F-18-labelled at the 6 position so that the label cannot be lost during such glycoside hydrolysis and which, further, cannot be phosphorylated. The mechanism-based glycosidase inhibitor 2,6-dideoxy-2-fluoro-6-{[}F-18]-fluoro-beta -D-glucopyranosyl fluoride (2,6FGF) was synthesized in 69\% overall chemical yield and in 9\% radiochemical yield (decay corrected) as a potential imaging probe for glycosidase.}, issn = {0362-4803}, doi = {10.1002/jlcr.466}, author = {Wong, AW and ADAM, MJ and Withers, SG} }