@article { ISI:000314664200006,
	title = {The {\textquoteleft}mirror-image{\textquoteright} postulate as a guide to the selection and evaluation of pyrrolidines as alpha-L-fucosidase inhibitors},
	journal = {CARBOHYDRATE RESEARCH},
	volume = {367},
	year = {2013},
	month = {FEB 15},
	pages = {29-32},
	abstract = {The ability of a series of pyrrolidines to inhibit several glycosidases was investigated. Using Fleet{\textquoteright}s {\textquoteleft}mirror-image postulate{\textquoteright}, it was proposed that enantiomeric derivatives of 1,4-dideoxy-1,4-imino-D-lyxitol (a known alpha-D-galactosidase inhibitor) would show inhibitory activity against alpha-L-fucosidases. Some modest alpha-L-fucosidase inhibitory activity was observed for selected compounds (particularly an aminomethyl pyrrolidine) and it was proposed that better activity could be obtained by modifying the C-2 side chain of the pyrrolidine core. The D-galacto carbamate scaffold also exhibited somewhat selective, albeit modest, alpha-L-fucosidase inhibitory activity and may prove to be an interesting scaffold for further development. (C) 2012 Elsevier Ltd. All rights reserved.},
	issn = {0008-6215},
	doi = {10.1016/j.carres.2012.11.011},
	author = {Stocker, Bridget L. and Jongkees, Seino A. K. and Win-Mason, Anna L. and Dangerfield, Emma M. and Withers, Stephen G. and Timmer, Mattie S. M.}
}
