@article { ISI:000340079800020, title = {2-Pyridonate Tantalum Complexes for the Intermolecular Hydroaminoalkylation of Sterically Demanding Alkenes}, journal = {Journal of the American Chemical Society}, volume = {136}, number = {31}, year = {2014}, month = {AUG 6}, pages = {10898-10901}, abstract = {

The design and synthesis of a mixed 2-pyridonate-Ta(NMe2)(3)Cl complex for the direct C-H alkylation adjacent to nitrogen in unprotected secondary amines are reported. The hydroaminoalkylation of sterically demanding internal alkenes gives the direct, catalytic formation of C(sp(3))-C(sp(3)) bonds. Substrate scope investigations reveal key strategies for further catalyst development efforts in this 100\% atom-economic synthesis of alpha-alkylated amines.

}, issn = {0002-7863}, doi = {10.1021/ja506187m}, author = {Chong, Eugene and Brandt, Jason W. and Schafer, Laurel L.} }