@article {C1OB05359K,
	title = {A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain},
	journal = {Org. Biomol. Chem.},
	volume = {9},
	year = {2011},
	pages = {6949-6954},
	publisher = {The Royal Society of Chemistry},
	abstract = {The enzymatic incorporation of a phenol-modified 2[prime or minute]-deoxyuridine triphosphate gave rise to a modified DNA library that was subsequently used in an in vitro selection for ribophosphodiester-cleaving DNAzymes in the presence of divalent zinc and magnesium cations. After 11 rounds of selection{,} cloning and sequencing resulted in 14 distinct sequences{,} the most active of which was Dz11-17PheO. Dz11-17PheO self-cleaved an embedded ribocytidine with an observed rate constant of 0.20 +/- 0.02 min-1 in the presence of 10 mM Mg2+ and 1 mM Zn2+ at room temperature. The activity was inhibited at low concentrations of Hg2+ cations and somewhat higher concentrations of Eu3+ cations.},
	doi = {10.1039/C1OB05359K},
	url = {http://dx.doi.org/10.1039/C1OB05359K},
	author = {Lam, Curtis H. and Hipolito, Christopher J. and Hollenstein, Marcel and Perrin, David M.}
}
