@article { ISI:000318588900029,
	title = {Tantalum Catalyzed Hydroaminoalkylation for the Synthesis of alpha- and beta-Substituted N-Heterocycles},
	journal = {Organic Letters},
	volume = {15},
	number = {9},
	year = {2013},
	month = {MAY 3},
	pages = {2182-2185},
	abstract = {<p>Unprotected secondary amines are directly alkylated by C-H functionalization adjacent to nitrogen, thereby opening new routes toward the synthesis of alpha- and beta-alkylated N-heterocycles. alpha-Alkylated piperidine, piperazine, and azepane products are prepared from heterocycles and alkenes in an atom-economic reaction with excellent regio- and diastereoselectivity. beta-Alkylated N-heterocycles are synthesized via a scalable one-pot alkylation/cyclization procedure generating 3-methylated azetidines, pyrrolidines, and piperidines.</p>},
	issn = {1523-7060},
	doi = {10.1021/ol400729v},
	author = {Payne, Philippa R. and Garcia, Pierre and Eisenberger, Patrick and Yim, Jacky C. -H. and Schafer, Laurel L.}
}
