@article {doi:10.1021/acs.orglett.5b03535,
	title = {Total Synthesis of K777: Successful Application of Transition-Metal-Catalyzed Alkyne Hydrothiolation toward the Modular Synthesis of a Potent Cysteine Protease Inhibitor},
	journal = {Organic Letters},
	volume = {18},
	number = {3},
	year = {2016},
	note = {PMID: 26811991},
	pages = {492-495},
	abstract = {We report the total synthesis of K777 and a series of analogues via alkyne hydrothiolation catalyzed by Wilkinson{\textquoteright}s complex (ClRh(PPh3)3). The alkyne hydrothiolation reactions proceeded with excellent regio- and diastereoselectivity to generate the desired E-linear vinyl sulfides in high yield. The use of Ellman{\textquoteright}s auxiliary generates the requisite propargyl amines in excellent enantiomeric excess (ee) and obviates the use of l-homophenylalanine, an expensive unnatural amino acid. The vinyl sulfone derivatives exhibit a large difference in rate toward Michael addition. Kinetic data are consistent with rate-limiting nucleophilic attack to generate the carbanion intermediate.},
	doi = {10.1021/acs.orglett.5b03535},
	url = {http://dx.doi.org/10.1021/acs.orglett.5b03535},
	author = {Erica R. Kiemele and Matthew Wathier and Paul Bichler and Jennifer A. Love}
}
