@article {JIANG2019,
	title = {Simultaneous determination of multiple components in cigarettes by mechanochemical extraction and direct analysis in real time mass spectrometry in minutes},
	journal = {Analytica Chimica Acta},
	volume = {1057},
	year = {2019},
	month = {05/2019},
	pages = {70-79},
	abstract = {<p>A simple, rapid and high throughput analytical approach with combination of mechanochemical extraction (MCE) and direct analysis in real time mass spectrometry (DART-MS) analysis was developed for the simultaneous determination of multiple chemical components in cigarette fillers. Different kinds of substances including nicotine, cigarette alkaloids, carbohydrates, organic acids, humectants and other additives were successfully extracted using MCE and detected by high resolution DART-MS. Six solvents of various polarities were compared during MCE process and significant differences were observed. Different brands of cigarettes as well as standard research cigarette exhibited distinctive chemical features and DART-MS fingerprints. Principle component analysis showed clear differentiation among different cigarettes extracted with the same solvent and different solvent extracts of the same type of cigarette. The putative chemical formulas were proposed based on accurate m/z values with \&lt;10 ppm mass errors. The relative contents of nicotine and other identified substances were compared and significant differences were observed among cigarettes of different locations. The whole procedure of MCE combined with DART-MS only takes minutes from raw cigarette fillers to obtaining the semi-quantitative results. The operation is simple and high throughput, providing an efficient method to analyze cigarette composition, and to establish a methodology to acquire the rapid cigarette fingerprints for quality control.</p>},
	keywords = {Cigarette filler, direct analysis in real time mass spectrometry, Mechanochemical extraction, Principle component analysis},
	issn = {0003-2670},
	doi = {https://doi.org/10.1016/j.aca.2019.01.024},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267019300935},
	author = {Qing Jiang and Diya Dai and Hongli Li and David D.Y. Chen}
}
