@article { ISI:000456318800013,
	title = {Regiocontrolled and Stereoselective Syntheses of Tetrahydrophthalazine Derivatives using Radical Cyclizations},
	journal = {CHEMISTRY-A EUROPEAN JOURNAL},
	volume = {25},
	number = {4},
	year = {2019},
	month = {JAN 18},
	pages = {976-980},
	abstract = {Tetrahydrophthalazine derivatives have found important applications in pharmaceutical research, but existing synthetic methods are unable to access them regio- and stereoselectively. Here, a new approach is presented that addresses these challenges by utilizing a 6-endo-trig radical cyclization in the key step. The desired tetrahydrophthalazines can be accessed in high yields (55-98 \%) and high diastereoselectivities for the trans-product (>95:5) starting either from readily accessible hydrazones, or from the corresponding aldehydes and substituted Boc-hydrazides in a one-pot process. The synthetic versatility of the tetrahydrophthalazine core was demonstrated by its straightforward conversion to dihydro-phthalazines, phthalazines, or pyrazolo dione derivatives. Furthermore, the N-N bond was reduced to afford a new route to 1,4-diamines.},
	issn = {0947-6539},
	doi = {10.1002/chem.201805249},
	author = {Zhang, Wei and Mo, Jia Yi and He, Weiying and Kennepohl, Pierre and Sammis, Glenn M.}
}
