@article {31534,
	title = {Catalytic and Atom-Economic C -C Bond Formation: Alkyl Tantalum Ureates for Hydroaminoalkylation},
	journal = {Angewandte Chemie International Edition},
	volume = {57},
	year = {2018},
	pages = {3469-3472},
	abstract = {<p>Abstract Atom-economic and regioselective C \&minus;C bond formation has been achieved by rapid C\&minus;H alkylation of unprotected secondary arylamines with unactivated alkenes. The combination of Ta(CH2SiMe3)3Cl2, and a ureate N,O-chelating-ligand salt gives catalytic systems prepared in situ that can realize high yields of β-alkylated aniline derivatives from either terminal or internal alkene substrates. These new catalyst systems realize C\&minus;H alkylation in as little as one hour and for the first time a 1:1 stoichiometry of alkene and amine substrates results in high yielding syntheses of isolated amine products by simple filtration and concentration.</p>},
	keywords = {AMINES, C-H activation, HYDROAMINOALKYLATION, tantalum alkyls, ureates},
	doi = {10.1002/anie.201712668},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201712668},
	author = {DiPucchio, Rebecca C. and Ro{\c s}ca, Sorin-Claudiu and Schafer, Laurel L.}
}
