@article {31540,
	title = {Early transition metal-catalyzed C{\textendash}H alkylation: hydroaminoalkylation for Csp3{\textendash}Csp3 bond formation in the synthesis of selectively substituted amines},
	journal = {Chem. Commun.},
	volume = {54},
	year = {2018},
	pages = {12543-12560},
	abstract = {<p>Hydroaminoalkylation is a 100\% atom economic method for forming Csp3\&ndash;Csp3 bonds through C\&ndash;H activation α to an amine and subsequent reaction with an alkene. When catalyzed by early transition metals{,} this reaction allows for alternative disconnections for the synthesis of structurally complex amines. This method avoids the installation of protecting groups or directing groups and does not require added oxidants{,} or photoredox catalysts. In this feature article{,} we discuss the various selectively substituted amines that can be accessed by hydroaminoalkylation{,} with a special focus on the development of early transition metal catalysts for their rapid{,} step and atom efficient assembly.</p>},
	doi = {10.1039/C8CC06445H},
	url = {http://dx.doi.org/10.1039/C8CC06445H},
	author = {Edwards, P. M. and Schafer, L. L.}
}
