@article { ISI:000461270300002,
	title = {Reversible C-N Bond Formation in the Zirconium-Catalyzed Intermolecular Hydroamination of 2-Vinylpyridine},
	journal = {Organometallics},
	volume = {38},
	number = {5},
	year = {2019},
	month = {02/2019},
	pages = {1011-1016},
	abstract = {<p>The intermolecular hydroamination of alkenes with alkylamines has been a long-standing challenge in catalysis, partially due to the near-thermoneutral nature of this transformation. Consistent with this understanding, we report the direct observation of reversible C-N bond formation in hydroamination. A bis(ureate) zirconium complex catalyzed the intermolecular hydroamination of 2-vinylpyridine. Reversible C-N bond formation was characterized by variable-temperature NMR spectroscopy, and thermodynamic parameters were determined using van\&$\#$39;t Hoff plots. Isolated intermediates support an aza-Michaeladdition mechanism. Sensitivity to steric bulk in the C-N bond forming step provided further evidence for the kinetically accessible but limited thermodynamic driving force for this transformation.</p>},
	issn = {0276-7333},
	doi = {10.1021/acs.organomet.8b00904},
	author = {Griffin, Samuel E. and Pacheco, Javier and Schafer, Laurel L.}
}
