@article {DI2021100753,
	title = {Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis},
	journal = {Bone Reports},
	volume = {14},
	year = {2021},
	month = {02/2021},
	pages = {100753},
	abstract = {<p>Purpose The purpose of this study was to evaluate the efficacy and toxicity of a novel lanthanum compound, La(XT), in an ovariectomized (OVX) rat model of osteoporosis. Methods Twenty-four ovariectomized female Sprague Dawley rats were divided into 3 groups receiving a research diet with/without treatment compounds (alendronate: 3\&nbsp;mg/kg; La(XT) 100\&nbsp;mg/kg) for three months. At the time of sacrifice, the kidney, liver, brain, lung and spleen were collected for histological examination. The trabecular bone structure of the tibiae was evaluated using micro-CT and a three-point metaphyseal mechanical test was used to evaluate bone failure load and stiffness. Results No significant differences were noted in plasma levels of calcium, phosphorus, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) between the La(XT) treatment compared to the non-treated OVX group. Alendronate-treated animals (positive control) showed higher BV/TV, Tb.N and lower Tb.Th and Tb.Sp when compared to the non-treated OVX group. Mechanical analysis indicated that stiffness was higher in the alendronate (32.88\%, p\&nbsp;=\&nbsp;0.04) when compared to the non-treated OVX group. Failure load did not differ among the groups. Conclusions No kidney or liver toxicities of La(XT) treatments were found during the three-month study. The absence of liver and kidney toxicity with drug treatment for 3\&nbsp;months, as well as the increased trabecular bone stiffness are encouraging for the pursuit of further studies with La(XT) for a longer duration of time.</p>},
	keywords = {La(XT), LANTHANUM, osteoporosis, OVX, TOXICITY},
	issn = {2352-1872},
	doi = {https://doi.org/10.1016/j.bonr.2021.100753},
	url = {https://www.sciencedirect.com/science/article/pii/S2352187221000085},
	author = {Yunyun Di and Ellen K. Wasan and Jacqueline Cawthray and Jaweria Syeda and Munawar Ali and David M.L. Cooper and Ahmad Al-Dissi and Nima Ashjaee and Wubin Cheng and James Johnston and David M. Weekes and Thomas I. Kostelnik and Chris Orvig and Kishor M. Wasan}
}
