@article {D1DT02685B,
	title = {Inorganic radiopharmaceutical chemistry of oxine},
	journal = {Dalton Trans.},
	volume = {50},
	year = {2021},
	month = {10/2021},
	pages = {16451-16458.  Invited Frontiers article.  HOT article},
	publisher = {The Royal Society of Chemistry},
	abstract = {<p>8-Hydroxyquinoline (8-HQ{,} oxine) is a small{,} monoprotic{,} bicyclic aromatic compound and its relative donor group orientation imparts impressive bidentate metal chelating abilities that have been exploited in a vast array of applications over decades. 8-HQ and its derivatives have been explored in medicinal applications including anti-neurodegeneration{,} anticancer properties{,} and antimicrobial activities. One long established use of 8-HQ in medicinal inorganic chemistry is the coordination of radioactive isotopes of metal ions in nuclear medicine. The metal-oxine complex with the single photon emission computed tomography (SPECT) imaging isotope [111In]In3+ was developed in the 1970s and 1980s to radiolabel leukocytes for inflammation and infection imaging. The [111In][In(oxine)3] complex functions as an ionophore: a moderately stable lipophilic complex to enter cells; however{,} inside the cell environment [111In]In3+ undergoes exchange and remains localized. As new developments have progressed towards radiopharmaceuticals capable of both imaging and therapy (theranostics){,} 8-HQ has been re-explored in recent years to investigate its potential to chelate larger radiometal ions with longer half-lives and different indications. Further{,} metal-oxine complexes have been used to study liposomes and other nanomaterials by tracking these nanomedicines in vivo. Expanding 8-HQ to multidentate ligands for highly thermodynamically stable and kinetically inert complexes has increased the possibilities of this small molecule in nuclear medicine. This article outlines the historic use of metal-oxine complexes in inorganic radiopharmaceutical chemistry{,} with a focus on recent advances highlighting the possibilities of developing higher denticity{,} targeted bifunctional chelators with 8-HQ.</p>},
	doi = {10.1039/D1DT02685B},
	url = {http://dx.doi.org/10.1039/D1DT02685B},
	author = {Southcott, Lily and Orvig, Chris}
}
