@article {35108,
	title = {Influence of host{\textendash}guest interactions on analytical performance of direct analysis in real-time mass spectrometry},
	journal = {Analytical and Bioanalytical Chemistry},
	year = {2023},
	month = {01/2023},
	type = {Research},
	abstract = {<p>To systematically study the influence of host\&ndash;guest interactions on the analytical performance of direct analysis in real time mass spectrometry (DART-MS), the interactions between cyclodextrins (CDs) and different Sudan dyes were investigated. The results showed that the host\&ndash;guest interaction between CDs and Sudan dyes did not affect qualitative analysis of the target compounds, but led to a lower signal intensity for Sudan dyes, thus affecting quantitative analysis of the target compounds. The stronger the host\&ndash;guest interaction, the weaker the signal intensity of target compound on DART-MS. The results also show that both in solution and in solid-phase microextraction (SPME), the addition of organic solvents can weaken the host\&ndash;guest interaction between CDs and Sudan dyes, thus improving the signal intensity in DART-MS. In SPME, adding organic solvents has a certain practical value and can improve the efficiency of Sudan dye analysis. This study suggests that appropriate sample pretreatment is needed to weaken noncovalent interactions prior to DART-MS analysis to obtain more accurate quantitative results. The data provide some insight into the effects of other noncovalent interactions on the efficiency of DART-MS as an analytical tool, as well as the potential to study intermolecular interactions with DART-MS.</p>},
	doi = {10.1007/s00216-023-04539-4},
	url = {https://doi.org/10.1007/s00216-023-04539-4},
	author = {Liu, Min and Wang, Simin and Ge, Wuxia and Bi, Wentao and Chen, D.D.Y.}
}
