@article {35332,
	title = {The Catalytic Synthesis of N-Aryl Indoles Featuring an Alternative Disconnection. Hydroaminoalkylation for a Telescoped Reaction Sequence},
	journal = {Organic Letters},
	volume = {24},
	year = {2022},
	chapter = {6571-6575},
	abstract = {<p>A tricatalytic telescoped synthesis toward C3-methyl-N-aryl indoline and indole products is reported. An in situ generated tantalum(V) ureate catalyst is used for the hydroaminoalkylation of o-chlorostyrene with N-methylaniline to first make a Csp3-Csp3 bond. Subsequent nickel-catalyzed C\&ndash;N coupling forms N-aryl indolines, and if desired, subsequent oxidation to N-aryl indoles can be achieved using catalytic [Cu(MeCN)4]BF4 and tert-butylperoxy-2-ethylhexyl carbonate as the terminal oxidant. This strategy highlights an alternative C\&ndash;C bond disconnection for the synthesis of indoles, which is enabled by the atom-economic hydroaminoalkylation reaction. The method was streamlined using a three-step, two-pot approach to afford up to 73\% overall isolated yield of variously substituted C3-methyl-N-aryl indoles.</p>},
	author = {Zheng, C. H. M. and Balatsky, D. A. and DiPucchio, R. C. and Schafer, L. L.}
}
