@article {Rothchild2024-ii,
	title = {Two {iron(II)}, $\alpha$-ketoglutarate-dependent enzymes encoded by the {PPZ} gene cluster of Metarhizium majus enable production of 8-hydroxyperamine},
	journal = {J. Am. Chem. Soc.},
	volume = {146},
	number = {15},
	year = {2024},
	pages = {10263{\textendash}10267},
	abstract = {Entomopathogenic fungus Metarhizium majus contains the nine-gene PPZ cluster, with ppzA, encoding a peramine-producing nonribosomal peptide synthetase, as the central component. In this work, the roles of two $\alpha$-ketoglutarate, iron-dependent oxygenases encoded by the PPZ genes ppzC and ppzD were elucidated. PpzD was found to produce both trans-4-hydroxy-l-proline and trans-3-hydroxy-l-proline in a 13.1:1 ratio, yielding a key precursor for peramine biosynthesis. PpzC was found to act directly on peramine, yielding the novel analogue 8-hydroxyperamine.},
	author = {Rothchild, Kristina W and Hagar, Mostafa and Berry, Daniel and Ryan, Katherine S}
}
