@article {Hagar2024-wf,
	title = {Piperazate-guided isolation of caveamides A and B, cyclohexenylalanine-containing nonribosomal peptides from a cave actinomycete},
	journal = {Org. Lett.},
	volume = {26},
	number = {19},
	year = {2024},
	pages = {4127{\textendash}4131},
	publisher = {American Chemical Society (ACS)},
	abstract = {Hybrid genome-mining/15N-NMR was used to target compounds containing piperazate (Piz) residues, leading to the discovery of caveamides A (1) and B (2) from Streptomyces sp. strain BE230, isolated from New Rankin Cave (Missouri). Caveamides are highly dynamic molecules containing an unprecedented $\beta$-ketoamide polyketide fragment, two Piz residues, and a new N-methyl-cyclohexenylalanine residue. Caveamide B (2) exhibited nanomolar cytotoxicity against several cancer cell lines and nanomolar antimicrobial activity against MRSA and E. coli.},
	author = {Hagar, Mostafa and Morgan, Kalindi D and Stumpf, Spencer D and Tsingos, Maya and Banuelos, Carmen A and Sadar, Marianne D and Blodgett, Joshua A V and Andersen, Raymond J and Ryan, Katherine S}
}
