@inbook {1679, title = {New Tools for Life Science Research Based on Fiber-Optic-Linked Raman and Resonance Raman Spectroscopy}, booktitle = {New Approaches in Biomedical Spectroscopy}, series = {Acs Symposium Series}, volume = {963}, year = {2007}, note = {ISI Document Delivery No.: BKS87Times Cited: 2Cited Reference Count: 17Blades, M. W. Schulze, H. G. Konorov, S. O. Addison, C. J. Jirasek, A. I. Turner, R. F. B.Proceedings PaperSymposium on Approaches in Biomedical Spectroscopy2005Honolulu, HIAmer Chem Soc1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA}, pages = {1-13}, publisher = {Amer Chemical Soc}, organization = {Amer Chemical Soc}, address = {Washington}, abstract = {Fiber-optic probes can exploit a favorable excitation radiation distribution within the sample that allows the use of higher laser power levels which, in turn, can yield a higher signal-to-noise ratio (SNR) for a given experiment without increasing the risk of analyte photo-damage. We have developed specialized fiber-optic probes for ultraviolet resonance Raman spectroscopy (UVRRS) that offer several advantages over conventional excitation/collection methods used for UVRRS. These probes are ideally suited for UVRRS studies involving biopolymers and small bio-molecules, in both native (e.g. physiological) and non-native (e.g. anoxic) solution environments. We have also developed novel probes based on hollow-core photonic band-gap fibers that virtually eliminate the generation of silica Raman scattering within the excitation fiber which often limits the utility of fiber-optic Raman probes in turbid media or near surfaces. These probes may offer advantages for some biomedical applications.}, keywords = {1, 2-DIOXYGENASE, PHOTONIC-CRYSTAL FIBER, PICOSECOND PULSES}, isbn = {0097-6156978-0-8412-7437-2}, url = {://000269122900001}, author = {Blades, M. W. and Schulze, H. G. and Konorov, S. O. and Addison, C. J. and Jirasek, A. I. and Turner, R. F. B.}, editor = {Kneipp, K. and Aroca, R. and Kneipp, H. and Wen trupByrne, E.} }