@article {2298, title = {Biomimetic synthesis of the IDO inhibitors exiguamine A and B}, journal = {Nature Chemical Biology}, volume = {4}, number = {9}, year = {2008}, note = {ISI Document Delivery No.: 339SNTimes Cited: 7Cited Reference Count: 19Volgraf, Matthew Lumb, Jean-Philip Brastianos, Harry C. Carr, Gavin Chung, Marco K. W. Muenzel, Martin Mauk, A. Grant Andersen, Raymond J. Trauner, Dirk}, month = {Sep}, pages = {535-537}, type = {Article}, abstract = {Biomimetic synthesis is an attempt to assemble natural products along biosynthetic lines without recourse to the full enzymatic machinery of nature. We exemplify this with a total synthesis of exiguamine A and the newly isolated natural product exiguamine B. The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3-dioxygenase inhibitors.}, keywords = {3-DIOXYGENASE, ANALOGS, CANCER, CASCADE, CELLS, ELECTROCYCLIZATIONS, EXPRESSION, INDOLEAMINE 2}, isbn = {1552-4450}, url = {://000258597700011}, author = {Volgraf, M. and Lumb, J. P. and Brastianos, H. C. and Carr, G. and Chung, M. K. W. and Munzel, M. and Mauk, A. G. and Andersen, R. J. and Trauner, D.} }