@article {1148,
	title = {Ceratamines, structurally simple microtubule-stabilizing antimitotic agents with unusual cellular effects},
	journal = {Cancer Research},
	volume = {65},
	number = {8},
	year = {2005},
	note = {ISI Document Delivery No.: 916ZFTimes Cited: 14Cited Reference Count: 9},
	month = {Apr},
	pages = {3040-3043},
	type = {Article},
	abstract = {Ceratamine A and ceratamine B are heterocyclic alkaloids recently identified in a screen for compounds that arrest cells in mitosis. Treatment of breast carcinoma MCF-7 cells causes a concentration-dependent block of cell cycle progression exclusively at mitosis. In vitro studies with purified tubulin indicate that the ceratamines directly stimulate microtubule polymerization in the absence of microtubule-associated proteins. Cells treated with ceratamines show a dense perinuclear microtubule network in interphase and multiple pillar-like tubulin structures in mitotic cells. The ceratamines do not compete with paclitaxel for binding to microtubules in vitro. Unlike other microtubule-stabilizing agents, the ceratamines have simple structures with no chiral centers, making them attractive drug leads.},
	keywords = {BIND, CELLS, RESISTANT, TAXOID SITE, TUBULIN},
	isbn = {0008-5472},
	url = {<Go to ISI>://000228424800012},
	author = {Karjala, G. and Chan, Q. and Manzo, E. and Andersen, R. J. and Roberge, N.}
}
