@article {888,
	title = {Spiculoic acids A and B, new polyketides isolated from the Caribbean marine sponge Plakortis angulospiculatusi},
	journal = {Organic Letters},
	volume = {6},
	number = {1},
	year = {2004},
	note = {ISI Document Delivery No.: 760BKTimes Cited: 21Cited Reference Count: 14},
	month = {Jan},
	pages = {75-78},
	type = {Article},
	abstract = {Two novel polyketides, spiculoic acids A (1) and B (2), have been isolated from extracts of the Caribbean marine sponge Plakortis angulospiculatus. The structures of 1 and 2 were elucidated by detailed analysis of spectroscopic data. Spiculoic acid A (1) showed in vitro cytotoxicity against human breast cancer MCF-7 cells. It has a putative polyketide biogenetic origin that involves incorporation of four butyrate units and a Diels Alderase catalyzed intramolecular [4 + 2] cycloaddition reaction.},
	keywords = {HALICHONDRIOIDES, PAPUA-NEW-GUINEA, PLAKOTENIN},
	isbn = {1523-7060},
	url = {<Go to ISI>://000187790500020},
	author = {Huang, X. H. and Van Soest, R. and Roberge, M. and Andersen, R. J.}
}
