@article {3982, title = {Massetolides A-H, antimycobacterial cyclic depsipeptides produced by two pseudomonads isolated from marine habitats}, journal = {Journal of Natural Products}, volume = {60}, number = {3}, year = {1997}, note = {ISI Document Delivery No.: WP603Times Cited: 52Cited Reference Count: 16}, month = {Mar}, pages = {223-229}, type = {Article}, abstract = {Massetolides A-H (1-8), novel cyclic depsipetides, and the known compound viscosin (9) have been isolated from cultures of two Pseudomonas sp. isolated from a marine alga and a marine tube worm, respectively. Massetolide A (1) and viscosin (9) exhibit in vitro antimicrobial activity against Mycobacterium tuberculosis and Mycobacterium avium-intracellulare. Precursor-directed biosynthesis has been used to generate unnatural massetolides 11-13 incorporating nonprotein amino acids.}, keywords = {BACTERIA, biosynthesis, METABOLITES}, isbn = {0163-3864}, url = {://A1997WP60300006}, author = {Gerard, J. and Lloyd, R. and Barsby, T. and Haden, P. and Kelly, M. T. and Andersen, R. J.} }