@article {11050,
	title = {A hierarchical classification of polysaccharide lyases for glycogenomics},
	journal = {Biochemical Journal},
	volume = {432},
	year = {2010},
	note = {Lombard, Vincent Bernard, Thomas Rancurel, Corinne Brumer, Harry Coutinho, Pedro M. Henrissat, Bernard Part 3},
	pages = {437-444},
	abstract = {Carbohydrate-active enzymes face huge substrate diversity in a highly selective manner using only a limited number of available folds. They are therefore subjected to multiple divergent and convergent evolutionary events. This and their frequent modularity render their functional annotation in genomes difficult in a number of cases. In the present paper, a classification of polysaccharide lyases (the enzymes that cleave polysaccharides using an elimination instead of a hydrolytic mechanism) is shown thoroughly for the first time. Based on the analysis of a large panel of experimentally characterized polysaccharide lyases, we examined the correlation of various enzyme properties with the three levels of the classification: fold, family and subfamily. The resulting hierarchical classification, which should help annotate relevant genes in genomic efforts, is available and constantly updated at the Carbohydrate-Active Enzymes Database (http://www.cazy.org).},
	doi = {10.1042/BJ20101185},
	author = {Lombard, V. and Bernard, T. and Rancurel, C. and Brumer, Harry and Coutinho, P. M. and Henrissat, B.}
}
